Mass spectrometric fingerprint for corona antibodies
Source: BAM, Protein Analysis and Organic Trace and Food Analysis
Antibodies are essential components for modern diagnostic tests. During the ongoing corona pandemic, many have been confronted with these assays for the first time. However, the different quality of the quick tests offered by a multitude of suppliers has confused many users. Independent quality examinations are only sensible if the respective assays and their reagents can be identified undoubtedly. In this work, mass spectrometry (MS) was used to identify antibody-based reagents. After mass spectrometric analysis, antibody fingerprints are compared and identified by an open-source software tool. A final result is delivered in less than one hour. We propose that each commercial antibody should be provided with a molecular fingerprint to be recognizable at any time and context. Falsifications, quality issues and undeclared product changes can be detected quickly.
MALDI-TOF-MS-Based Identification of Monoclonal Murine Anti-SARS-CoV-2 Antibodies within One Hour
Georg Tscheuschner, Melanie N. Kaiser, Jan Lisec, D. Beslic, Thilo Muth, M. Krüger, H. W. Mages, B. G. Dorner, J. Knospe, J. A. Schenk, F. Sellrie, Michael G. Weller
published in Antibodies, Vol. 11, issue 2, article 27, pages 1 - 22, 2022
BAM division Protein Analysis and division Organic Trace and Food Analysis and
section e-Science