25/11/2021 03:00 PM


25/11/2021 04:30 PM



see link below

Organized by

Bundesanstalt für Materialforschung und -prüfung

Grafik zur Veranstaltungsreihe Wissenschaft mit Wirkung

Source: BAM

Since 1871, BAM has been ensuring safety in technology and chemistry to build confidence in innovations and new technologies. Through our work we strengthen Germany as a business location and address social challenges such as the energy transition or climate change.

As part of the lecture series "Science with Impact", BAM has invited thought leaders from the scientific community to discuss BAM's developments in its focus areas and their impact on society. You are cordially invited to attend the virtual lectures.

See also BAM's anniversary website.

Lecture on 25 November 2021

Prof. Dr. Wolfgang Parak
CHyN, Universität Hamburg

DateThursday, 25 November 2021, 03:00 pm
Type of EventWebinar
TopicQuantitative evaluation of the cellular entry and excretion of colloidal nanoparticles
PresenterProf. Dr. Wolfgang Parak
CHyN, Universität Hamburg
Hamburg, Germany
SummaryNanomaterials play a promising role in the advancements of technology and health care. Their nanometric size combined with particular optoelectronic, magnetic, or plasmonic properties makes them suitable candidates for theranostics, biosensing, and bioimaging applications. This led to intensive investigation of the interaction of nanoparticles (NPs) with cells. Whereas most studies are focused on how the physicochemical properties of NPs will influence their uptake by cells, much less is known about their potential excretion from cells. However, to control and manipulate the number of NPs in a cell both, cellular uptake and excretion need to be studied quantitatively. Monitoring the intracellular and extracellular amount of NPs, after residual non-internalized NPs have been removed, over time enables to disentangle the influence of cell proliferation and exocytosis, which are the major pathways for the reduction of NPs per cell. Proliferation depends on the type of cells, and exocytosis depends on the size of the NPs. Examples are given on the role of these two different processes for different cells and NPs.

Webex - Prof. Dr. Wolfgang Parak