06/02/2018 11:00 AM
06/02/2018 01:00 PM
Bundesanstalt für Materialforschung und -prüfung
Branch Adlershof, Building 8.05, Lecture Hall
Bundesanstalt für Materialforschung und -prüfung, IGAFA, Analytical City Adlershof, SALSA, Humboldt Univerität zu Berlin
Advancements in Compound-specific Isotope Analysis (CSIA): Perspectives for Studying Reaction Mechanisms in Complex Systems
Prof. Dr. Martin Elsner
Technische Universität München, Institute for Hydrochemistry; Chair of
Analytical Chemistry and Water Chemistry &
Helmholtz Zentrum München – Research Center for Environmental Health
Prof. Dr. Janina Kneipp (HUB/SALSA)
Dr. habil. Rudolf Schneider (BAM)
Investigating organic transformation mechanisms in complex environments (ground and surface water, living organisms, heterogeneous catalysis) is of fundamental importance in chemical sciences, yet challenged by the uncertainty whether lab-based studies adequately mirror real-world processes. Compound-specific stable isotope analysis (CSIA) of organic substances at natural isotopic abundance offers the potential to bridge this gap and to enable mechanistic reaction studies directly in complex systems. Through gas chromatography (GC) or liquid chromatography (LC) coupled to isotope ratio mass spectrometry (IRMS) the measurement of 13C-, 15N-, 2H- and 37Cl- isotope effects can be accomplished in pesticides, pharmaceuticals, chlorinated hydrocarbons and petroleum hydrocarbons at trace (microgram per liter) concentrations.
This information does not only allow detecting degradation of chemicals in the environment in complex situations and over time scales otherwise not accessible (months to years). Isotope effect analysis of multiple elements also enables to elucidate transformation mechanisms (i.e. the manner and order of bond breaking) where conventional
analysis provides complementary information about the identity of products (i.e. the net outcome of a reaction). This offers prospects for studying degradation of chemicals in rivers, groundwater and engineered systems.