Beginn

12.05.2021 00:00 Uhr

Ende

12.05.2021 00:00 Uhr

Veranstaltungsort

Online Event

Link siehe unten

Veranstalter

Bundesanstalt für Materialforschung und -prüfung, Abteilung Analytische Chemie; Referenzmaterialien

Grafik zur Veranstaltungsreihe Wissenschaft mit Wirkung

Quelle: BAM

Since 1871, BAM has been ensuring safety in technology and chemistry to build confidence in innovations and new technologies. Through our work we strengthen Germany as a business location and address social challenges such as the energy transition or climate change.

As part of the lecture series "Science with Impact", BAM has invited thought leaders from the scientific community to discuss BAM's developments in its focus areas and their impact on society. You are cordially invited to attend the virtual lectures.

See also BAM's anniversary website.

Einladung
DateWednesday, 12 May 2021
Type of EventWebex
TopicNanocapsules: Challenges for Biomedical Applications
PresenterProf. Katharina Landfester, MPI Mainz
Summary

Our vision is to construct multipotent drug-loaded nanocapsules of high homogeneity in size and surface functionality, which find their target cells in the desired organs and release the drug in a controlled manner in the cytoplasm of these cells. For the delivery of bioactive compounds to a specific cell, it is not only vital to improve the stability of the therapeutic agent during passage through the blood stream, but also to extend the circulation time in the body.

Making smart nanoparticles is inevitably linked to a deep understanding of the overall physico-chemical principle of their formation. By means of the miniemulsion process, we design custom-made nanoparticles and nanocapsules for biomedical applications. This is facilitated by the enormous versatility of the miniemulsion process that has been developed and conceptually understood by our group. Moreover, the accumulation of understanding the formation process has led to successful and precise control of important nanoparticle parameters such as size, shape, morphology, surface functionalization and modification, degradation, release kinetics. This degree of control is unique and allows us to tune specific properties tailored to particular applications; the successful up-scaling of process is of technical relevance. Furthermore, the encapsulation and release of a great variety of payloads, ranging from hydrophobic to hydrophilic substances has been successfully achieved in a highly controlled manner and with an unmatched high encapsulation efficiency.

For biomedical application, many interactions to biological matter have to be considered and tuned: the interaction with blood components (proteins etc.) has to be controlled to limit aggregation processes. Furthermore, the interaction to cell membranes and uptake in blood cells like macrophages has to be minimized. Only then the drug can reach the target cells. The specific interaction to target cells have to be tuned.

LanguageEnglish
Link-Registration https://bam-bund.webex.com
Contact at BAMDr. Ute Resch-Genger, ute.resch[at]bam.de