Bioanalytics

Bioanalysis at BAM: Division 1.5 with the working groups Immunochemical Methods, Fluorescence Spectroscopy, Isotope Analysis and Bioanalytical Sensor Materials

Biochemistry and biotechnology are key technologies of the 21st century. With the classical borders between basic and product-specific research constantly vanishing, a multitude of novel products emerges. The pace and the dimension of the respective economic growth however depend on the public acceptance of the products and legal regulations. Work in the Division 1.5 is thus especially concerned with issues of normative harmonisation and supports attempts to method validation and the traceability and comparability of results by provision of reference materials and methods.

The Division 1.5 works on topics from all areas of bioanalytics:

• Analysis with biochemical reagents (e.g., monoclonal antibodies)
• Analysis of biochemical target compounds (e.g., peptides with MALDI-TOF-MS)
• Analysis in biological matrices (e.g., biofuels, toxins in food)
• Analysis in or of biological systems (e.g., optical tomography of tumors)

The aim is to achieve quantitative results with a defined uncertainty of measurement.

The Division 1.5 collaborates with industrial partners (e.g., SMEs), especially in the fields of pharmaceuticals and diagnostics, food and agricultural production as well as water and environmental analysis, and cooperates with national and international, academic and non-academic research institutions. Staff members of the Division teach at academic institutions in Berlin.

Areas of interest

• Preparation and characterization of biochemical standard reagents and reference materials
• Screening of robust and analytically useful affinity molecules
• Quality control (e.g., validation) in bioanalytics
• Optimization and characterization of fluorescent dyes
• Design of assays, haptens, chemosensors and biosensors
• Optical and enzymatic labels
• Signal amplification strategies and multiplexing for optical detection techniques
• Particle-based probes and sensor systems
• High-throughput techniques and microarray formats
• Stable isotope methods

Areas of competence and contacts

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